FourierPET: Deep Fourier-based Unrolled Network for Low-count PET Reconstruction

Low-count positron emission tomography (PET) reconstruction is a challenging inverse problem due to severe degradations arising from Poisson noise, photon scarcity, and attenuation correction errors. Existing deep learning methods typically address these in the spatial domain with an undifferentiated optimization objective, making it difficult to disentangle overlapping artifacts and limiting correction effectiveness. In this work, we perform a Fourier-domain analysis and reveal that these degradations are spectrally separable: Poisson noise and photon scarcity cause high-frequency phase perturbations, while attenuation errors suppress low-frequency amplitude components. Leveraging this insight, we propose FourierPET, a Fourier-based unrolled reconstruction framework grounded in the Alternating Direction Method of Multipliers. It consists of three tailored modules: a spectral consistency module that enforces global frequency alignment to maintain data fidelity, an amplitude-phase correction module that decouples and compensates for high-frequency phase distortions and low-frequency amplitude suppression, and a dual adjustment module that accelerates convergence during iterative reconstruction. Extensive experiments demonstrate that FourierPET achieves state-of-the-art performance with significantly fewer parameters, while offering enhanced interpretability through frequency-aware correction.

Cross-modal Proxy Evolving for OOD Detection with Vision-Language Models

Reliable zero-shot detection of out-of-distribution (OOD) inputs is critical for deploying vision-language models in open-world settings. However, the lack of labeled negatives in zero-shot OOD detection necessitates proxy signals that remain effective under distribution shift. Existing negative-label methods rely on a fixed set of textual proxies, which (i) sparsely sample the semantic space beyond in-distribution (ID) classes and (ii) remain static while only visual features drift, leading to cross-modal misalignment and unstable predictions. In this paper, we propose CoEvo, a training- and annotation-free test-time framework that performs bidirectional, sample-conditioned adaptation of both textual and visual proxies. Specifically, CoEvo introduces a proxy-aligned co-evolution mechanism to maintain two evolving proxy caches, which dynamically mines contextual textual negatives guided by test images and iteratively refines visual proxies, progressively realigning cross-modal similarities and enlarging local OOD margins. Finally, we dynamically re-weight the contributions of dual-modal proxies to obtain a calibrated OOD score that is robust to distribution shift. Extensive experiments on standard benchmarks demonstrate that CoEvo achieves state-of-the-art performance, improving AUROC by 1.33% and reducing FPR95 by 45.98% on ImageNet-1K compared to strong negative-label baselines.

Enabling Ultra-Fast Cardiovascular Imaging Across Heterogeneous Clinical Environments with a Generalist Foundation Model and Multimodal Database

Multimodal cardiovascular magnetic resonance (CMR) imaging provides comprehensive and non-invasive insights into cardiovascular disease (CVD) diagnosis and underlying mechanisms. Despite decades of advancements, its widespread clinical adoption remains constrained by prolonged scan times and heterogeneity across medical environments. This underscores the urgent need for a generalist reconstruction foundation model for ultra-fast CMR imaging, one capable of adapting across diverse imaging scenarios and serving as the essential substrate for all downstream analyses. To enable this goal, we curate MMCMR-427K, the largest and most comprehensive multimodal CMR k-space database to date, comprising 427,465 multi-coil k-space data paired with structured metadata across 13 international centers, 12 CMR modalities, 15 scanners, and 17 CVD categories in populations across three continents. Building on this unprecedented resource, we introduce CardioMM, a generalist reconstruction foundation model capable of dynamically adapting to heterogeneous fast CMR imaging scenarios. CardioMM unifies semantic contextual understanding with physics-informed data consistency to deliver robust reconstructions across varied scanners, protocols, and patient presentations. Comprehensive evaluations demonstrate that CardioMM achieves state-of-the-art performance in the internal centers and exhibits strong zero-shot generalization to unseen external settings. Even at imaging acceleration up to 24x, CardioMM reliably preserves key cardiac phenotypes, quantitative myocardial biomarkers, and diagnostic image quality, enabling a substantial increase in CMR examination throughput without compromising clinical integrity. Together, our open-access MMCMR-427K database and CardioMM framework establish a scalable pathway toward high-throughput, high-quality, and clinically accessible cardiovascular imaging.

GDKVM: Echocardiography Video Segmentation via Spatiotemporal Key-Value Memory with Gated Delta Rule

Accurate segmentation of cardiac chambers in echocardiography sequences is crucial for the quantitative analysis of cardiac function, aiding in clinical diagnosis and treatment. The imaging noise, artifacts, and the deformation and motion of the heart pose challenges to segmentation algorithms. While existing methods based on convolutional neural networks, Transformers, and space-time memory networks have improved segmentation accuracy, they often struggle with the trade-off between capturing long-range spatiotemporal dependencies and maintaining computational efficiency with fine-grained feature representation. In this paper, we introduce GDKVM, a novel architecture for echocardiography video segmentation. The model employs Linear Key-Value Association (LKVA) to effectively model inter-frame correlations, and introduces Gated Delta Rule (GDR) to efficiently store intermediate memory states. Key-Pixel Feature Fusion (KPFF) module is designed to integrate local and global features at multiple scales, enhancing robustness against boundary blurring and noise interference. We validated GDKVM on two mainstream echocardiography video datasets (CAMUS and EchoNet-Dynamic) and compared it with various state-of-the-art methods. Experimental results show that GDKVM outperforms existing approaches in terms of segmentation accuracy and robustness, while ensuring real-time performance. Code is available at https://github.com/wangrui2025/GDKVM.

Semiparametric Learning from Open-Set Label Shift Data

We study the open-set label shift problem, where the test data may include a novel class absent from training. This setting is challenging because both the class proportions and the distribution of the novel class are not identifiable without extra assumptions. Existing approaches often rely on restrictive separability conditions, prior knowledge, or computationally infeasible procedures, and some may lack theoretical guarantees. We propose a semiparametric density ratio model framework that ensures identifiability while allowing overlap between novel and known classes. Within this framework, we develop maximum empirical likelihood estimators and confidence intervals for class proportions, establish their asymptotic validity, and design a stable Expectation-Maximization algorithm for computation. We further construct an approximately optimal classifier based on posterior probabilities with theoretical guarantees. Simulations and a real data application confirm that our methods improve both estimation accuracy and classification performance compared with existing approaches.

Commander-GPT: Dividing and Routing for Multimodal Sarcasm Detection

Multimodal sarcasm understanding is a high-order cognitive task. Although large language models (LLMs) have shown impressive performance on many downstream NLP tasks, growing evidence suggests that they struggle with sarcasm understanding. In this paper, we propose Commander-GPT, a modular decision routing framework inspired by military command theory. Rather than relying on a single LLM's capability, Commander-GPT orchestrates a team of specialized LLM agents where each agent will be selectively assigned to a focused sub-task such as context modeling, sentiment analysis, etc. Their outputs are then routed back to the commander, which integrates the information and performs the final sarcasm judgment. To coordinate these agents, we introduce three types of centralized commanders: (1) a trained lightweight encoder-based commander (e.g., multi-modal BERT); (2) four small autoregressive language models, serving as moderately capable commanders (e.g., DeepSeek-VL); (3) two large LLM-based commander (Gemini Pro and GPT-4o) that performs task routing, output aggregation, and sarcasm decision-making in a zero-shot fashion. We evaluate Commander-GPT on the MMSD and MMSD 2.0 benchmarks, comparing five prompting strategies. Experimental results show that our framework achieves 4.4% and 11.7% improvement in F1 score over state-of-the-art (SoTA) baselines on average, demonstrating its effectiveness.

Adapting Vision-Language Foundation Model for Next Generation Medical Ultrasound Image Analysis

Medical ultrasonography is an essential imaging technique for examining superficial organs and tissues, including lymph nodes, breast, and thyroid. It employs high-frequency ultrasound waves to generate detailed images of the internal structures of the human body. However, manually contouring regions of interest in these images is a labor-intensive task that demands expertise and often results in inconsistent interpretations among individuals. Vision-language foundation models, which have excelled in various computer vision applications, present new opportunities for enhancing ultrasound image analysis. Yet, their performance is hindered by the significant differences between natural and medical imaging domains. This research seeks to overcome these challenges by developing domain adaptation methods for vision-language foundation models. In this study, we explore the fine-tuning pipeline for vision-language foundation models by utilizing large language model as text refiner with special-designed adaptation strategies and task-driven heads. Our approach has been extensively evaluated on six ultrasound datasets and two tasks: segmentation and classification. The experimental results show that our method can effectively improve the performance of vision-language foundation models for ultrasound image analysis, and outperform the existing state-of-the-art vision-language and pure foundation models. The source code of this study is available at https://github.com/jinggqu/NextGen-UIA.

Toward Reliable AR-Guided Surgical Navigation: Interactive Deformation Modeling with Data-Driven Biomechanics and Prompts

In augmented reality (AR)-guided surgical navigation, preoperative organ models are superimposed onto the patient's intraoperative anatomy to visualize critical structures such as vessels and tumors. Accurate deformation modeling is essential to maintain the reliability of AR overlays by ensuring alignment between preoperative models and the dynamically changing anatomy. Although the finite element method (FEM) offers physically plausible modeling, its high computational cost limits intraoperative applicability. Moreover, existing algorithms often fail to handle large anatomical changes, such as those induced by pneumoperitoneum or ligament dissection, leading to inaccurate anatomical correspondences and compromised AR guidance. To address these challenges, we propose a data-driven biomechanics algorithm that preserves FEM-level accuracy while improving computational efficiency. In addition, we introduce a novel human-in-the-loop mechanism into the deformation modeling process. This enables surgeons to interactively provide prompts to correct anatomical misalignments, thereby incorporating clinical expertise and allowing the model to adapt dynamically to complex surgical scenarios. Experiments on a publicly available dataset demonstrate that our algorithm achieves a mean target registration error of 3.42 mm. Incorporating surgeon prompts through the interactive framework further reduces the error to 2.78 mm, surpassing state-of-the-art methods in volumetric accuracy. These results highlight the ability of our framework to deliver efficient and accurate deformation modeling while enhancing surgeon-algorithm collaboration, paving the way for safer and more reliable computer-assisted surgeries.

Efficient Medical Vision-Language Alignment Through Adapting Masked Vision Models

Medical vision-language alignment through cross-modal contrastive learning shows promising performance in image-text matching tasks, such as retrieval and zero-shot classification. However, conventional cross-modal contrastive learning (CLIP-based) methods suffer from suboptimal visual representation capabilities, which also limits their effectiveness in vision-language alignment. In contrast, although the models pretrained via multimodal masked modeling struggle with direct cross-modal matching, they excel in visual representation. To address this contradiction, we propose ALTA (ALign Through Adapting), an efficient medical vision-language alignment method that utilizes only about 8% of the trainable parameters and less than 1/5 of the computational consumption required for masked record modeling. ALTA achieves superior performance in vision-language matching tasks like retrieval and zero-shot classification by adapting the pretrained vision model from masked record modeling. Additionally, we integrate temporal-multiview radiograph inputs to enhance the information consistency between radiographs and their corresponding descriptions in reports, further improving the vision-language alignment. Experimental evaluations show that ALTA outperforms the best-performing counterpart by over 4% absolute points in text-to-image accuracy and approximately 6% absolute points in image-to-text retrieval accuracy. The adaptation of vision-language models during efficient alignment also promotes better vision and language understanding. Code is publicly available at https://github.com/DopamineLcy/ALTA.

Are MLMs Trapped in the Visual Room?

Can multi-modal large models (MLMs) that can ``see'' an image be said to ``understand'' it? Drawing inspiration from Searle's Chinese Room, we propose the \textbf{Visual Room} argument: a system may process and describe every detail of visual inputs by following algorithmic rules, without genuinely comprehending the underlying intention. This dilemma challenges the prevailing assumption that perceptual mastery implies genuine understanding. In implementation, we introduce a two-tier evaluation framework spanning perception and cognition. The perception component evaluates whether MLMs can accurately capture the surface-level details of visual contents, where the cognitive component examines their ability to infer sarcasm polarity. To support this framework, We further introduce a high-quality multi-modal sarcasm dataset comprising both 924 static images and 100 dynamic videos. All sarcasm labels are annotated by the original authors and verified by independent reviewers to ensure clarity and consistency. We evaluate eight state-of-the-art (SoTA) MLMs. Our results highlight three key findings: (1) MLMs perform well on perception tasks; (2) even with correct perception, models exhibit an average error rate of ~16.1\% in sarcasm understanding, revealing a significant gap between seeing and understanding; (3) error analysis attributes this gap to deficiencies in emotional reasoning, commonsense inference, and context alignment. This work provides empirical grounding for the proposed Visual Room argument and offers a new evaluation paradigm for MLMs.